Abstract: Routine electroencephalograms (EEG) are notrecommended as a screen for epileptic discharges (EDs) in current practiceguidelines for children with autism spectrum disorder (ASD). However, a reviewof the research from the last three decades suggests that this practice shouldbe reevaluated. The significant comorbidity between epilepsy and ASD, itsshared biological pathways, risk for developmental regression, and cognitivechallenges demand increased clinical investigation requiring a proactive approach.This review highlights and explains the need for screening EEGs for childrenwith ASD. EEG would assist in differentiating EDs from core features of ASD andcould be included in a comprehensive assessment. EEG also meets the demand forevidence-based precision medicine and focused care for the individual,especially when overlapping processes of development are present.